|
KMID : 0191120130280030472
|
|
Journal of Korean Medical Science
2013 Volume.28 No. 3 p.472 ~ p.475
|
|
|
Two Cases of Refractory Thrombocytopenia in Systemic Lupus Erythematosus that Responded to Intravenous Low-Dose Cyclophosphamide
|
|
Park Hee-Jin
Kang Mi-il
Kang Yoon
Chung Soo-Jin
Lee Sang-Won
Park Yong-Beom
Lee Soo-Kon
|
|
|
Abstract
|
|
|
|
Treatment of thrombocytopenia in systemic lupus erythematosus (SLE) is considered in cases of current bleeding, severe bruising, or a platelet count below 50,000/μL. Corticosteroid is the first choice of medication for inducing remission, and immunosuppressive agents can be added when thrombocytopenia is refractory to corticosteroid or recurs despite it. We presented two SLE patients with thrombocytopenia who successfully induced remission after intravenous administration of low-dose cyclophosphamide (CYC) (500 mg fixed dose, biweekly for 3 months), followed by azathioprine (AZA) or mycophenolate mofetil (MMF). Both patients developed severe thrombocytopenia in SLE that did not respond to pulsed methylprednisolone therapy, and started the intravenous low-dose CYC therapy. In case 1, the platelet count increased to 50,000/μL after the first CYC infusion, and remission was maintained with low dose prednisolone and AZA. The case 2 achieved remission after three cycles of CYC, and the remission continued with low dose prednisolone and MMF
|
|
|
KEYWORD
|
|
|
Cyclophosphamide, Systemic Lupus Erythematosus, Thrombocytopenia
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|